Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles
Palabras clave:Chitosan, nanoparticles, biomedical, pharmaceuticals, toxicity
engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent dvances in chitosan derivatives ve nanaparticulas and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review themain concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safetyusing tissue cultures and animal models, and also their potential environmental impact. At the endnbof this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.
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